Endocrine Abstracts

A 26-year-old Chinese male with autism spectrum disorder and mental retardation, was referred to start insulin therapy for uncontrolled diabetes mellitus (DM) (HbA1c: 9%; C-peptide: 1.75 ng/ml; anti-GAD AB: negative) treated with oral antidiabetic drugs since 2012.Clinical examination revealed a tall man with overweight and truncal obesity in light of his ethnicity. We withheld facial dysmorphism with hypertelorism, scarce facial hair, and clinodactyly. ...

Background: Bone turnover markers are used in research and clinical practice, but only in part reflect bone formation and resorption. Components of the Wnt-signaling pathway, regulating osteoblastogenesis and osteoblast function, can be measured in serum, however it is unclear whether they reflect underlying bone mass and metabolism.Objective: Determine whether serum levels of Wnt-signalling components reflect bone mass or metabolism in men during growth...

Introduction: (Anti-TNF-α) therapy is widely used for the treatment of inflammatory diseases. The most frequent adverse events induced by anti-TNF-α therapy are infections and malignancies. However, reports of paradoxical sarcoidosis-like reactions are on the rise in patients receiving anti-TNF-α.Clinical case: A 61-year old woman, with a medical history of sero-positive rheumatoid arthritis on Adalimumab treatment (anti-TNF-α), was r...

Background: Thyroid incidentaloma are asymptomatic thyroid nodules that are discovered on an imaging study performed to evaluate other structures. Clinically unrecognized thyroid nodules are common and can be found in up to 50–60% of patients at autopsy.1 Increased use of imaging modalities of better quality in the modern era has resulted in an increased detection of incidental thyroid nodules. The prevalence rate is 67% with ultrasonography (US) imaging, 15% w...

Background: Data concerning pubertal development and testosterone (T) in obese male adolescents (ObA) are scarce and contrasting. Underperforming T immunoassays and poor assessment of pubertal development might explain discordant findings. Although SHBG is markedly affected, few studies report free T (FT) levels.Objective: To study if ObA have conserved FT levels despite low total T (TT) and to investigate if FT is a better indicator of androgen exposure...